2025 NFL Week 16 odds, betting: Full list of Week 16 spreads

The 2025-26 NFL regular season is about to enter its final stretch, and time is officially running out for the Kansas City Chiefs to make the playoffs after a 16-13 loss to the Los Angeles Chargers on Sunday in Week 15. Patrick Mahomes also tore his ACL, adding insult to injury for Kansas City.

It’s never too early to look ahead to next week, though, and sportsbooks have released lines for each game.

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Here are BetMGM’s odds for every NFL game in Week 16:

Thursday

Los Angeles Rams (-1.5, 44.5) at Seattle Seahawks

[Check out all of Yahoo’s sports betting content here in our new betting hub]

Sunday

1 p.m. ET

Philadelphia Eagles (-6, 44.5) vs. Washington Commanders

Green Bay Packers (-1.5, 46.5) at Chicago Bears

Buffalo Bills (-10, 42.5) vs. Cleveland Browns

Los Angeles Chargers vs. Dallas Cowboys (-1.5, 49.5)

Kansas City Chiefs (-3.5, 37.5) at Tennessee Titans

Cincinnati Bengals vs. Miami Dolphins (-1.5, 50.5)

New York Jets vs. New Orleans Saints (-4.5, 40.5)

Minnesota Vikings (-2.5, 44.5) at New York Giants

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Tampa Bay Buccaneers (-2.5, 45.5) Carolina Panthers

4 p.m. ET

Jacksonville Jaguars vs. Denver Broncos (-3, 45.5)

Atlanta Falcons (-1.5, 46.5) at Arizona Cardinals

Pittsburgh Steelers vs. Detroit Lions (-7, 49.5)

Las Vegas Raiders vs. Houston Texans (-14.5, 37.5)

sunday night football

New England Patriots vs. Baltimore Ravens (-2.5, 48.5)

on Monday

San Francisco 49ers (-5.5, 46.5) at Indianapolis Colts

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