2025 NFL Playoffs betting, odds: Los Angeles Rams (-10.5 at Panthers) are largest road favorites in the Super Bowl era

The first game of the 2025 NFL playoffs will pit the 12-5 Los Angeles Rams, one of the Super Bowl favorites with potential MVP quarterback Matthew Stafford, against the 8-9 division champion Carolina Panthers on Saturday afternoon.

Oddsmakers and bettors didn’t believe the game would be close — so much so that the Rams are now a historic road favorite.

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Los Angeles opened as a 10-point favorite over Carolina at BetMGM, and the line has moved to -10.5 (even as high as -11 at some bettors). If that line holds, the Rams would be the biggest road favorite in the Super Bowl era — dating back to 1966, according to sports betting history.

“We opened the Rams at -10, but so far it’s been a one-sided bet,” Thomas Gable, director of Borgata Sportsbook in Atlantic City, told Yahoo Sports on Wednesday. “All the public money has been spent on the Rams. We’re now at -10.5 and the overall odds are still 46.5.”

Tom Brady and the Tampa Bay Buccaneers are 10-point road favorites in the 2021 Washington Commanders, while the New Orleans Saints were 9.5-point or 10-point favorites in Marshawn Lynch’s famous “Beast Quake” game in 2010. points advantage against the Seattle Seahawks. Both weak teams were covered, with the Seahawks beating Drew Brees’ Saints 41-36.

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In fact, teams as road favorites by at least 4.5 points have gone 1-6-1 since 1966 and have only gone 4-4 straight up.

The Rams were 10-point favorites this season when they lost 31-28 to Carolina in Week 13, a game in which Bryce Young threw three touchdown passes and Stafford had three interceptions in one of his worst games of the year.

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Los Angeles is one of the better teams against the spread this season with a 12-5 record, while the Panthers are 10-7. Carolina has won all eight of its games as underdogs, but the Panthers improved to 8-0 on the season following the loss. Carolina lost to the Buccaneers in Week 18, 16-14.

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