Tonight, the Magpies, supported by more than 6,500 away fans, aim to reach the fifth round of the prestigious cup competition for the third consecutive season.
Eddie Howe made six changes to the starting XI to help his side beat Tottenham Hotspur 2-1 away in the Premier League on Tuesday night.
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Aaron Ramsdale, Lewis Hall, Sandro Tonali, William Orsula, Jacob Murphy and Nick Waltermade all replace Nick Pope, Sven Botman, Bruno Guimarães, Anthony Gordon, Anthony Elanga and Joe Willock.
After a 3-3 draw with Bournemouth at St James’ Park last month, United beat Bournemouth on penalties to advance to the fourth round.
Newcastle United traveled to the second city to play in the fourth round of last season’s FA Cup and came from behind to defeat Birmingham City 3-2.
Newcastle United: Aaron Ramsdale, Kieran Trippier (c), Lewis Hall, Sandro Tonali, Harvey Barnes, Malik Thio, William Osula, Jacob Murphy, Nick Waltermade, Dan Byrne, Jacob Ramsey.
Unused substitutes: Nick Pope, John Ruddy, Anthony Gordon, Anthony Elanga, Joe Willock, Alex Murphy, Leo Shahar, Sean Neave, Park Seung-soo.