Something Grim Is Happening to People Who Go Off GLP-1s

Many people who have successfully lost weight on Ozempic and other GLP-1 agonist medications have difficulty quitting the injections British Broadcasting Corporation, Weight creep begins again as hunger for food returns, suggesting that patients may develop a lifelong dependence on these substances.

“I was overweight for the first 38 years of my life – I now weigh 6 stone (38kg) [83 pounds] Tanya Hall, a Wegovy user who can’t quit drugs, told the news agency. “So I felt like I had an addiction and needed to keep doing drugs because it made me feel like myself and made me feel like I was in control.”

Research backs this up, finding that patients who stop using these drugs often regain significant weight gain. That’s why there are celebrities like Oprah, who told people magazine Last month, she made plans to keep going indefinitely. What this means: Many users will have to treat obesity as a chronic disease and need to take these drugs for life.

“This is going to be a lifetime thing,” Oprah said. “I was on medication for high blood pressure, and if I stopped taking it, my blood pressure would go up. I realized that’s the same now with these medications. I’ve proven to myself that I need it.”

For patients who stop taking the drug, they tend to regain two-thirds of their weight, according to research from Novo Nordisk, the maker of Ozempic. Dr. Hussein Zubaidi told British Broadcasting Corporation He has seen patients lose 60 to 80 percent of their weight.

Zubaidi said it may seem like a hopeless task, but all is not lost. Patients should have an “exit strategy” to make healthier lifestyle changes while injecting drugs; lifestyle changes can maintain weight loss once they are completely detoxified, he said.

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This is what happened to Ellen Ogley, she told British Broadcasting Corporation She lost 48.5 pounds while taking Eli Lily’s GLP-1 drug Mounjaro. While on the medication, she established healthier eating habits and incorporated exercise into her daily routine. Even after being off the medication for a while, she was still able to maintain her weight loss.

“I want people to know that life after Monzaro can be sustainable,” she said.

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