The Buffalo Bills and their “X-Factor” will continue their 2025 NFL season in Week 16 against the Cleveland Browns.
While game plans, coaching and strategy all play a role, sometimes the focus is on certain individual players. As far as the defense goes, who will they be?
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Here are Bills Wire’s three potential X-factors in the Bills (10-4) offense against the Browns (3-11):
RB James Cook
DETROIT, MI – NOVEMBER 20: Jeremiah Owusu-Koramoah #28 of the Cleveland Browns and AJ Green #38 of the Cleveland Browns go against James Cook #28 of the Buffalo Bills during the third quarter at Ford Field on November 20, 2022 in Detroit, Michigan. (Photo by Gregory Shams/Getty Images)
While the Bills have staged a comeback in recent weeks under quarterback Josh Allen, this game should and needs to get easier. Cook can shorten the game by being a running back, and a score or two wouldn’t hurt either.
OL Dion Dawkins
September 28, 2025; Orchard Park, New York, USA; Buffalo Bills offensive tackle Dion Dawkins (73) on the sidelines during the second quarter of the Bills’ game against the New Orleans Saints at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images
While the Browns are struggling, pass rusher Myles Garrett is not. He is elite. While Garrett is looking for the NFL’s single-season sack record, Dawkins will have his hands full.
WR Keon Coleman
December 14, 2025; Foxborough, MA, USA; New England Patriots cornerback Carlton Davis III (7) is penalized for pass interference, disrupting a catch by Buffalo Bills wide receiver Keon Coleman (0) during the second half at Gillette Stadium. Mandatory Credit: Brian Fluharty-Imagn Images
The Bills can make a big play with Coleman on the floor. One or two of them will deflate the Browns, who have little to play for.
This article originally appeared on Bills Wire: 3 X-factors for Bills in Browns offense in Week 16
