An committee said on Thursday that after the scandal of genetically modified babies in China two ago, techniques on human embryos should be used until they are proven to be reliable and safe.

from the National Academy of Medicine, the National Academy of Sciences, and the Royal Society said that heritable genome editing for medical purposes is “not ready” to be tried safely and effectively in human embryos.

The corpse was established after Chinese biophysicist He Jiankui triggered an international scandal in 2018. The scandal claimed that he was behind the world’s baby to use Crispr for gene editing. Crispr is a powerful new tool that can serve as A kind of molecular “scissors”.

Ignoring ethical and scientific norms, he created the twins of Lula and Nula, whose genomes have changed to give them immunity against HIV.

In December last , he was sentenced to three years in prison for illegal medical practice by a Chinese court.

The case shocked scientists all over the world, raised questions about bioethics and global scientific research supervision, and once again inspired people’s concerns about parents creating so-called “design babies”.

The committee stated that the event clearly demonstrated the risk of “temporary editorial work that may cause significant harm to individuals”.

It said: “Furthermore, considering that heritable changes will be introduced and passed on to future generations, it is clear that the specific application of editing techniques needs to be carefully considered.”

The report says that heritable genome editing involves altering the genetic material of human eggs, or any cells that lead to their development, including cells from early embryos. many countries.

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The committee is composed of 18 experts from different disciplines. It does not reject the principle of human genetic modification, but aims to provide a framework for countries considering the use of the technology.

It acknowledged that gene editing “may be an important option for prospective parents with known genetic disease risks, allowing them to give birth to genetically related children without the disease and its associated morbidity and mortality.”

But it says in its recommendations that unless it has been “clearly determined” that changes can be made reliably without “unnecessary changes”, genome editing of embryos should not be used to produce pregnancy.

It said it has not yet reached the standard and requires countries to conduct further research and “extensive social dialogue” before deciding to allow genetic editing of the human genome.

Kay Davis, co-chair of the University Genetics Professors Committee, said: “These technologies should be used strictly. Based on a strict understanding of how pathogen mutations cause diseases, it is important to apply these technologies to medically reasonable interventions. “Oxford university

“More research on genome editing technology in human embryos is needed to ensure that precise changes can be made without undesirable off-target effects. International cooperation and open discussions on all aspects of genome editing will be essential.”

The report of the committee will be put into work by the World Health Organization (WHO), has established a committee responsible for the management of genetic and non-hereditary human genome editing research and clinical applications. The WHO committee is expected to issue guidance later this year.

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