shutterstock 755581951

In the United States, black people are at higher risk for several health conditions. Heart disease, high blood pressure, type 2 diabetes, and stroke [usually chronic diseases] do. This is also for Alzheimer's disease Blacks are twice as likely Than whites.

So why are these differences, especially in Alzheimer's disease, which is usually not considered a chronic disease, but a progressive disease, or worsens over time?

Some researchers attribute the gap to social and systemic related to Inequality in education, socioeconomics, income and access to health care. Other such as stress, diet, lifestyle and Genetics may also help. However, there is an open question in Alzheimer's disease that may lead to this difference: Are the underlying biology of the disease different between blacks and non-Hispanic whites?

I am a Basic science researcher People studying racial differences in Alzheimer's disease. I have started to discover that the biological basis of this disease may not be the same in African Americans and non-Hispanic whites.

mine laboratory Multiple are underway to better understand the biological characteristics of African-American Alzheimer's disease and whether non-Hispanic whites may be the same or different. We will share our initial findings soon, as this work is necessary to help understand the root cause of this difference. More importantly, it will help us understand the disease for everyone.

I think that many contribute to the health differences in Alzheimer's disease, and biology is a very worthwhile area to explore. Even considering clinical trials of Alzheimer's disease, Black representatives have less than 5% of participantsAnd they represent 13% of the U.S. population. This makes it difficult to know whether and how these potential therapies work for blacks and other underrepresented populations. This makes it important to understand the biology of the differences, as it may affect the development and effectiveness of potential therapies.

See also  Travel ban this week, gig economy risk and more car news

Search for clues

Genetic may be a factor in racial differences in Alzheimer's disease. In the general population, the genetic form of Alzheimer's disease accounts for Less than 5% of all cases.

Among African Americans Some genes It has been determined to be associated with a higher risk of Alzheimer's disease specific to this population. one is ABCA7. Several independent studies have shown that this gene can cause high risk Disease Among African Americans Used to develop Alzheimer's disease.

ABCA7 gene participation Lipid transportThis is important for moving lipids or fatty acids in the blood and brain. However, our researchers have not fully understood how this gene or other genes increase the risk of African Americans.

It is almost obvious that the higher incidence of diseases experienced African Americans, including Alzheimer's, must be associated with it. For example, high blood pressure increases the risk of Alzheimer's disease, and 40% of African American adults have high blood pressure. Is it possible that similar biological are driving these high morbidity rates in both diseases?

We begin to answer this question $ 4.2 million reward Recently received from the National Institutes of Health. We will study proteins in the blood of African Americans with hypertension or Alzheimer's disease. comparing our findings in these subpopulations, we will be able to determine whether the biological characteristics of the two diseases are similar. For fewer participants, we will be able to study proteins in the brain of an autopsy. We expect some preliminary results in early 2021.

See also  Scientists discover a mysterious "ghost bloodline" in West African genes

For example, in Our own work with other'sWe believe that differences in inflammation and lipid metabolism may be responsible for some differences in Alzheimer's disease.

Does the protein in the brain differ?

In a preliminary study, we compared thousands of proteins-one called Proteomics – Three different autopsy brain regions from African-American and non-Hispanic whites. We found that many proteins associated with Alzheimer's disease are the same in African Americans and non-Hispanic whites, but we were surprised to find changes associated with Alzheimer's disease that is unique to African Americans . We are conducting research to replicate these findings.

However, this result raises some points. First, researchers can learn more about the biology of Alzheimer's disease ensuring that the study population includes a diverse, especially disparate, population of subjects. Second, the subsurface manifestations of the disease may vary in different populations. It is important to understand this in order to develop a diagnosis or therapy that can be adjusted accordingly. Finally, in order to bring us closer to finding a cure for the disease, more such research must be conducted.

Large "omics" studies that can measure thousands of genes, proteins, lipids, and metabolites, when applied to ethnic differences in Alzheimer's disease, will provide a wealth of information to help explain why these differences exist. Other researchers are beginning to apply these techniques. Recently, researchers confirmed the importance of inflammation in Alzheimer's disease and noted Specific inflammatory genes Appears only among African-American or non-Hispanic whites. In addition, in Amyloid and tau biomarkers for Alzheimer's diseaseRecent work has proven that race is an important factor in establishing these biomarkers.

See also  U.S. stocks: Wall Street slumps on opening as California virus emergency prompts California emergency

The truth of things is when we use PubMed database To study the omics of African Americans with Alzheimer's disease, we found that African Americans were severely underrepresented. Many studies have excluded African Americans. So even starting to explain why differences exist [reducing and eliminating them much less] is challenging because basic science research is not enough to include African Americans.

Including different groups in basic science research and clinical trials of Alzheimer's disease is a key first step to helping reduce and eliminate health differences. This will give us a better understanding of the disease. It will facilitate the search for diagnostic markers or therapies faster, resulting in strategies that effectively help everyone.

Two more promising clinical trials recently Alzheimer's drugs failWe need to have a complete understanding of the disease. The medical community can best achieve this ensuring that blacks, Hispanics, and other diverse groups are included in all research, especially in basic science research.

This article was republished from The Conversation under a Creative Commons license. Read the original article.